The Effectiveness and Safety of Direct Oral Anticoagulants in Obese Patients With Atrial Fibrillation: A Network Meta-Analysis

Atrial fibrillation (AF) is a cardiac condition characterized by an irregular heart rhythm, which increasingly prevalent in the modern era. All international guidelines strongly advise administration of anticoagulants to individuals with AF who are at high risk stroke. These recommend use direct oral (DOACs) over warfarin because significantly associated increased rates major bleeding, numerous interactions food and drugs, necessity for frequent monitoring. The aim this study compare effectiveness safety obese patients atrial fibrillation. Two authors independently conducted comprehensive literature search using electronic databases including PubMed, CINAHL, EMBASE from inception June 1, 2023. efficacy outcome assessed meta-analysis included composite stroke systemic embolism. For analysis, bleeding events were compared among groups. Eleven studies fulfilled all inclusion criteria present enrolling 144,502 patients. In study, DOACs demonstrate superior preventing stroke/systemic embolism warfarin. Among DOACs, apixaban emerged as most effective, followed rivaroxaban, warfarin, dabigatran. terms safety, was also found be favorable treatment option, dabigatran, summary, our concludes that exhibited greater when other AF.